|
KMID : 1098420090170030217
|
|
Korean Journal of Medicinal Crop Science
2009 Volume.17 No. 3 p.217 ~ p.222
|
|
|
Immunomodulatory Effects of phellinus linteus Extracts on Liver Damage Induced by Carbon Tetrachloride in Rats
|
|
An Chi-Sun
Choi Se-Yong
Lim Beong-Ou
Kim Hae-Ran
Jeon Yun-Hui
Hur Sun-Jin
Kim Ick-Hee
Park Geum-Duck
Jeoung Young-Jun
|
|
|
Abstract
|
|
|
|
The purpose of this study evaluated the immunoregulatory effect of phellinus linteus ethanol (PLE) extracts on liver damage on carbon tetrachloride (CCl4) induced in rats. Four-week old Male Sprague-Dawley rats were divided into the three experimental groups randomly; Control group, CCl4 group, CCl4 + PLE group. We found that effect of PLE on IFN-γ, STAT1 and pSTAT1 was decrease in vivo. Several genes were demonstrated to be IL-4 inducible prior to the discovery of STAT6. IL-4, STAT6 and pSTAT6 decreased significantly lower in CCl4 + PLE than the CCl4 group. Our data indicated that cytokine protein production were increased in CCl4 group with CCl4 + PLE group. In our data indicate that IgA levels in MLN lymphocytes were low, while IgE was high in CCl4 + PLE group compared with CCl4 group. Therefore, the results of this study show that PLE can be proposed to protect the liver against CCl4-induced immunoregulatory activity in rats.
|
|
|
KEYWORD
|
|
|
Phellinus linteus, CCl4, Nitric Oxide, IL-4, IFN-γ, STAT1/STAT6
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|